Novel ω-N-amino analogs of B13 (Class E) were designed, synthesized and tested as inhibitors of acid ceramidase (ACDase) and potential anticancer agents deprived of unwanted lysosomal destabilization and ACDase proteolytic degradation properties of LCL204 [Szulc, Z. M.; Mayroo, N.; Bai, A.; Bielawski, J.; Liu, X.; Norris, J. S.; Hannun, Y. A.; Bielawska, A. Bioorg. Med. Chem. 2008, 16, 1015].
Again Smith emphasises the agent's situation, and asks how the spectator would feel if in the agent's situation, deprived of everything that matters to people.
The metasomatic agent that is deprived of F must be derived from the basalt and sediment portion of the oceanic lithosphere.
By infusing chemotherapeutic agents directly into vessels supplying the tumor, and subsequently obstructing these vessels with an embolization material, the HCC receives prolonged exposure to the chemotherapeutic agent, and is deprived of its' blood supply.
During pretrial proceedings that lasted well over a year, Yunis's defense attorney launched a series of successful challenges, asserting that Yunis had been improperly charged, that FBI agents had willfully deprived Yunis of his rights in order to obtain a confession, and that the US government was not providing access to classified documents that were necessary for Yunis's defense.
Agents can be deprived of their autonomy by brainwashing, depression, anxiety, fatigue; they can succumb to compulsions and addictions.
The Justice Department announced last year that prosecutors lacked sufficient evidence to make charges that agents had willfully deprived Hernández Rojas of a constitutional right, violated a federal manslaughter statute, or they "deployed the taser or restrained Hernandez-Rojas with malice".
Autophagy can promote cell survival by removing old or damaged cellular organelles, which are frequently used by cancer cells to supply deprived nutrients induced by therapeutic agents.
We conclude that there is little advantage and some limitations in using mice thus deprived; (7) One of the agents used for immunological deprivation silica powder markedly decreased the rate of I loss from mice injected with labelled killed myeloblasts.
"The government's delay," Mr. Hogan said, "follows a pattern of the Secret Service stonewalling plaintiffs and ignoring court orders, depriving African-American agents of the fundamental evidence of race discrimination that is key to their claims".
