The participants in the eszopiclone and fluoxetine group that were more severely depressed at baseline experienced the most significant changes in depressive symptoms at Week 4 (p = 0.005) and Week 8 (p = 0.0007).
For each patient, we displayed the number of depressive symptoms per week in a time-series plot over 104 weeks and plotted the frequency distribution of the symptoms, i.e., collapsed over measurements, as a histogram of 104 scores.
One third (38, 37.6%) were classified as having significant depressive symptoms at week 6 using the GDS-15.
For each patient, we displayed the number of depressive symptoms per week as individual time-series plots.
For instance, patients who were more distressed and frightened during ACS showed higher levels of anxiety and depressive symptoms, one week and three months, respectively, after the cardiac event [ 3].
Hence, the symptom "waking up with worry or anxiety" was defined to be present if the prevalence was "At least once per week", "depressive mood" if the answers were from "Sometimes" to "All the time" and "impaired self-assessed quality of life" if answers were from "Low" to "Moderate".
Counselling/relaxation was also found to be effective in reducing mild/moderate depressive symptoms 6 weeks after therapy in patients with gynaecological cancer (HADS mild/moderate depression subscale, P=0.02) but not severe levels of depressive symptoms (GHQ-28 Major depressive symptoms subscale, NS; Petersen and Quinlivan, 2002).
Two subjects required the addition of an antidepressant for treatment of depressive symptoms starting from week 12 (V9) and week 20 (V11), respectively.
And they are angry that doctors, who confirmed Lubitz had "shown symptoms suggesting a psychotic depressive episode" just weeks before the crash, refused to speak to investigators, citing patient confidentiality.
Rude et al. (2002) found scores on the SST to predict depressive symptoms 4 6 weeks later.
