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In contrast, patients with major depression in intervention practices were at no greater risk than were people without depression (hazard ratio 1.09, 0.83 to 1.44).
Patients with major depression in usual care were more likely to die than were those without depression (hazard ratio 1.90, 95% confidence interval 1.57 to 2.31).
In the basic model (that is, adjusted for age, sex and year of treatment), hazard ratios showed a lower risk of treated depression (hazard ratio 0.69, 95% confidence interval 0.60 to 0.80) and all cause mortality (0.37, 0.26 to 0.54) in patients prescribed varenicline than in those prescribed nicotine replacement therapy.
In a population-based cohort study – InCHIANTI – of 888 frail older adults aged ≥65 years with follow-up at 3, 6, and 9 years, 30.6% of nondepressed persons developed depressed mood during follow-up, and the presence of frailty conferred a significant risk of new onset of depression (Hazard ratio [HR] =1.26; 95% CI =1.09 1.45) in adjusted models.
On a bivariate level, having a lower FEV1 %pred (hazard ratio = 0.95, 95%CI = 0.93 0.97), a lower exercise capacity (Wpeak; hazard ratio = 0.97, 95%CI = 0.95 0.98), and having more symptoms of depression (hazard ratio = 1.08, 95%CI = 1.01 1.15) are significantly related to mortality in patients with COPD in our sample.
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There was no evidence that varenicline was associated with an increased risk of depression (n=2244) (hazard ratio 0.88 (0.77 tor.00)) or suicidal thoughts (n=37) (1.43 (0.53 to 3.85)).
In unadjusted models, both depression symptoms (hazard ratio 1.31 [95% CI 1.03 1.67], P = 0.03) and antidepressant use noted at the study visit 6 months previously (1.72 [1.37–2.15], P < 0.0001) were predictors of weight regain.
In unadjusted analyses, both depression symptoms (hazard ratio 1.31 [95% CI 1.03 1.67], P = 0.03) and antidepressant medication use at either the previous visit (1.72 [1.37–2.15], P < 0.0001) or cumulatively as percent of visits (1.005 [1.002 1.008], P = 0.0003) were predictors of subsequent weight regain.
One study examined whether being diagnosed with both an anxiety disorder and a depression increases the hazard-ratio for death during follow-up compared to only one of these disorders.
A man would have to be holder than we are, & feel considerably more rejection-proof, to hazard the depression McMillen threathens us with, should we try to pick up some of his coverage.
Compared with control subjects, diabetic patients had a significantly increased hazard of depression (HR 1.43 [95% CI 1.16 1.77]).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com