Assuming a causal relationship between depression and the progression of CF, our hypothesis is that elevated symptoms of depression would be a predictor of worse lung function after two years.
The interaction between depression and disease progression could be linked to the lack of hope, optimism and perceived self-efficacy in depressed patients, consequently inhibiting their fighting spirit against the disease and necessary adherence to treatment.
While Markov models have served – and continue to serve – the scientific and decision-making communities well, we are of the opinion that DES also offers additional possibilities for modelling patients with depression and their progression through the healthcare system.
If untreated, NPS can lead to significant morbidity and mortality including increased cost, distress, depression, and faster disease progression, as well as heightened burden on families.
Moreover, it has a direct association with depression and HIV disease progression [ 8].
Heart muscle damaged during MI is replaced by a collagenous scar over a period of several weeks, and the mechanical properties of that scar tissue are a key determinant of serious post-MI complications such as infarct rupture, depression of heart function, and progression to heart failure.
However, the clinical literature regarding the impact of pre-existing depression on cancer risk and progression remains divided and poorly controlled.
Both guidelines made clear, albeit differing, statements on the importance of depression in the onset and progression of coronary heart disease.
The role of psychological variables, particularly those of anxiety and depression in disease progression and clinical outcome has received attention from the research community.
And with progress and progression comes adaptation.
