Results of initial studies led to the design of a new cannula that could effectively deliver anecortave acetate as a posterior juxtascleral depot, providing adequate retinal and choroidal drug concentrations for up to 6 months after a single administration.
The final depot provides a porous but stable three-dimensional (3-D) scaffold for the long-term insulin delivery in a glucose-mediated fashion.
It is proposed that the unique mechanism of protraction of IDeg, based on soluble multihexamer formation in the subcutaneous depot, provides a buffering effect against changes in absorption rate, which thereby contributes to a stable and more consistent activity.
Several white and brown adipose depots provided by the animal facility of our Department were collected from female CD-1 mice.
Regenerative medicine requires innovative therapeutic designs to accommodate high morphogen concentrations in local depots, provide their sustained presence, and enhance cellular invasion and directed differentiation.
Human milk banks and milk depots provide pasteurized donor milk to our most vulnerable infants.
In its early years, the depot also provided furniture when the court, numbering over 1,000 people, traveled abroad for affairs of state like coronations and weddings.
In all cases the chief/responsible hospital pharmacists of the hospital pharmacies, and in one case a "pharmaceutical depot", personally provided the price data and were available for the interview.
The introduction of LA depot formulations provided a significant improvement in the acceptance of this therapy; however, their indicated treatment duration of 1 to 4 months was still not long enough to satisfy all medical needs.
