It remains possible that loss of Top2 alters H1 deposition, a possibility that we were unable to test due to the inability of our H1 antibodies to work in immunohistochemical analyses.
Considering the large synaptic changes seen in 2-month-old TASTPM mice in the CA1 region, despite the lack of plaque deposition, one possibility was that the effects seen were developmental, due to the position of transgene insertion or overexpression of the APP and/or PSEN1, independent of increasing amyloid-β levels.
One potential explanation is that cadmium's effect on lung function requires airborne exposure and pulmonary deposition, a possibility also noted by Hendrick (2004) when commenting on the same phenomenon in Mannino et al.'s (2004) study of cadmium and lung function in NHANES III data.
The high lateral propagation rate of the metal strip during metal deposition offers possibilities for metallization of insulating microstructures.
Furthermore, negative charge-rich Al2O3 films together with optimization of the a-Si H i) film deposition ha-Si H ipossibility to improve the a-Si:H(i)/Al2O3 stack passivation efilmt.
Electron beam induced deposition offers the possibility of building three-dimensional structures with very high resolution, thus allowing design of all kinds of electrical and optical micro- and nano-devices.
Intensity-modulated radiation therapy (IMRT) not only shapes the beams geometrically but modulates the fluence of the beams providing improved dose deposition with the possibility of both concave and convex isodose distributions.
Modern thin film deposition technologies present possibilities to produce such film structures, both from process and control perspectives.
Optically Stimulated Luminescence (OSL) dating of these deposits indicates formation between 44 and 20 ka, with the possibility that deposition occurred during two phases of rapid sedimentation at ca. 42 and 25 ka.
New techniques that allow visualization of amyloid deposition offer an exciting possibility of detection of disease in its earliest possible stages but may not be as useful as cognitive measures, imaging techniques or other biomarkers for monitoring changes in the brain that occur between the MCI and dementia stages of AD.
