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The lack of further depletion of the second administration might be due the possibility of the induction of rat anti-mouse antibodies, which were unfortunately not evaluated.
Further, depletion of the second messenger PKCϵ (with an oligodeoxynucleotide antisense) also prevents the development of the hyperalgesia (male rats) [ 31].
We also show that depletion of the second isoform of eEF1A (which is 95% identical to eEF1A1 and can clearly fulfill, by itself, the translational requirements of a cell as it is the only eEF1A isoform expressed in muscle cells and neurons) does not have any effect on HSR.
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Our second study isolates the effect of direct willpower depletion on the first day of a two-day period, thus exploring procrastination over a shorter time horizon.
I can think of four reasons straight off: any depletion of the fourth estate is to be regretted – who else will shine a light on the machinations of government?
Although, for long distances, there is a marginal extension in the depletion of the first node, the overall lifetime of the network remains reasonably extended in terms of the half and last node depletions.
Substrates were added at the beginning of the experiment and a second addition was performed after complete depletion of the first load.
A further indication that the GlcCer transfer activity of FAPP2 is relevant for its role in membrane trafficking at the TGN comes from the observation that some of the phenotypes induced by FAPP2 silencing are mimicked by the depletion of the first enzyme involved in GSL synthesis, namely glucosylceramide synthase (GCS) [10].
After local depletion of antioxidants, the first oxidative stress products can be measured within 1 h.
Specifically, haploinsufficiency of TCOF1 leads to lowered levels of Treacle, which in turn leads to depletion of the NCC precursors of the first and second visceral arches (Dixon et al. 2006).
The transient nature of this current might be due to "run-down" caused by the depletion of intracellular second messengers induced by whole-cell recording, but we believe that this is unlikely due to the very rapid nature by which the current diminishes.
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