Dynamic causal modeling corroborated and extended these findings by showing that 5-HT depletion reduced the influence of processing angry vs. neutral faces on circuits within PFC and on PFC amygdala pathways.
It is generally thought that miRNAs represent highly stable molecules and, experimentally using RNA polymerase II inhibitors or depletion of miRNA processing enzymes, have indicated that the half-lives of miRNAs in cell lines or in organs such as liver or heart correspond to many hours or even days (Gatfield et al., 2009; Großhans and Chatterjee, 2010; Krol et al., 2010; van Rooij et al., 2007).
The pattern of findings was thought to be indicative of a depletion of available cognitive processing resources because of the need for continuous allocation of resources to monitoring.
Taken together, data obtained both in single and in multi-compartment models strongly suggested that depletion of APP dimer processing represents a major molecular mechanism in the pathology of Alzheimer's disease.
Depletion of the miRNA processing enzyme Dicer in the epidermis results in hyperproliferation [ 9], and several miRNAs have been shown to modulate keratinocytes proliferation, such as miR-34 family [ 10], miR-125b [ 11], miR-200 family [ 12], miR-203 [ 13], and miR-210 [ 14].
Level of processing: Moderately processed.
The European Activation SYstem has been re-engineered and re-written in modern programming languages so as to answer today's and tomorrow's needs in terms of activation, transmutation, depletion, decay and processing of radioactive materials.
On the other hand, depletion of argonaute proteins impaired the processing of precursor, indicating the requirement of these proteins for the stabilization of miRNAs [ 14].
Depletion of splicing factors causes defective processing of the pre-mRNA encoding sororin, a factor required for the stable association of cohesin with chromatin, and an associated reduction of sororin protein level.
These injury specific variables can be addressed only by relating all measurements to raw, unprocessed sample volume regardless of depletion and other processing steps including optimizing protein amounts for trypsin digestion or immunoassay applications.
