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After in silico depletion of error-containing sequences, and chimeras as well as sequencing reads assigned to plant mitochondria, we identified 1,374 prokaryotic operational taxonomic units (OTUs) at 97% sequence similarity (Database S1; Experimental Procedures).
RNAi-induced depletion of hCdc14B causes errors in chromosome segregation, metaphase delay, multipolar spindles, and cell death due to accumulation of multiple mitotic defects.
The molecular mechanism(s) by which ribavirin inhibits viral replication, such as depletion of intracellular GTP pools and induction of error catastrophe, may not readily allow the design of analogues that are more potent/selective than the parent drug.
Lots of error".
ZERO margin of error".
Error or cover up of error?
In case of error.
Dual depletion of Mbnl1 and Mbnl3 therefore initiates both Clc-1 splice errors and translation defects to synergistically enhance myotonia.
Furthermore, translational errors of proteins were caused by a depletion of the t-RNA pool owing to the high alanine and glycine content.
ClpP1P2 protease appears important in degrading missense and prematurely terminated peptides, as partial depletion of ClpP2 reduced growth specifically in the presence of antibiotics that increase errors in translation.
Conversely, inhibition or depletion of aurora B kinase, which over-stabilises kMT attachments (by reducing q), causes errors in chromosome alignment and segregation [ 7, 27, 30, 34, 35].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com