Sentence examples for depletion generated from inspiring English sources

Cells infected with shRNAs that resulted in a partial E-cadherin depletion generated polyclonal populations that either lost E-cadherin suppression over time (shEcad#24), or exhibited a partial reduction of E-cadherin levels for the duration of these studies (shEcad#23) (Figure 6A, B).

Sabnis and coworkers [ 8] now confirm that HER2 and PI3K/AKT signalling (but not MAPK) is upregulated and growth contributory in a new model (UMB-1Ca) of acquired resistance to oestrogen depletion generated from ER-positive aromatase-transfected MCF-7Ca cells in vitro.

IL-2, in association with Treg depletion, generates "hyperactivated" natural killer (NK) cells, possessing antitumor activity and secreting factors that facilitate virus spread/replication throughout the tumor by disrupting the tumor architecture.

Kosch et al. ([2007b]) showed that the pump beam forms a large-scale density depletion generating a reflective concave HF mirror which focuses the pump wave energy into a small region when pumping in the magnetic zenith.

Its overexpression interferes with protein synthesis and suppresses proliferation [26], while its depletion generates supernumerary centrosomes, multinucleated cells, and multipolar spindle formation in NIH3T3 cells [27].

Thus partial patch depletion generates novel niche opportunities, in a process related to niche construction [ 30, 31] or niche creation [ 32].

Another Rab described in this context is Rab6c, which is localized to the centrosome and whose overexpression results in G1-phase arrest and whose depletion generates tetraploid cells [ 49].

To rule out effects of c-Kit blockade on responses to physiological SCF sources, and to rule out antibody mediated depletion, we generated a SCF null 4T1 cell line (supplemental Fig. 6c, d).

To assess the long-term effect of prohibitin depletion, we generated HeLa cell lines with inducible shRNA expression.

To investigate the effects of prolonged JMJD2B depletion, we generated ZR-75-1 cells in which JMJD2B expression was knocked down using short hairpin RNA (shRNA; Figure S1D), and assessed the ability of these cells to form colonies in soft agar.

Third, we use the empirical null distribution to convert the depletion scores generated from the real data into q-values.