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Iron depletion augments the pulmonary hypertensive response to hypoxia, while iron loading greatly attenuates the phenomenon.
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The main results of this study are: 1) Mesencephalic dopamine depletion augmented significantly the pain caused by CCI-IoN.
Additionally, serotonin depletion likely augments hyperemic response after CSD in rat cerebral cortex due to increased NO production [ 149].
Whilst depletion of Treg augmented the 5T4-specific response in 1/14 of the CRC patients, depletion of this population led to the unmasking of a 5T4 response in 5/14 of the patients tested (95% Confidence Interval for paired differences is −0.83 to −0.22 revealing a significant difference in 5T4 responses between CRC patients and healthy controls).
Depletion of Sirt3 augmented apoptosis in the tumor cells treated with irradiation, as evidenced by increases in the level of cleaved PARP and Annexin V staining.
As neutrophil depletion just before infection augments the development of immunity to sand fly-transmitted infection and of a Leishmania-specific T-cell response, the capture of infected neutrophils by DCs in the skin was suggested as a key mechanism to inhibit their APC function and to delay the development of acquired resistance.
(A) Normoxic control with/without GSH depletion, (B) normoxic GSH augmented, (C) hypoxic control with/without GSH depletion and (D) hypoxic GSH augmented groups.
Depletion of CD14+ monocytes augmented mycobacteria-induced Vδ2+ cell expression of CD69 (Fig. 3d) and IFN-γ (data not shown), suggesting that in our system monocytes are inhibitory.
Depletion of CD4+CD25+ Treg cells augmented Gag-specific CD8 T cell responses, whereas gp120-specific T cells remained impaired in this context.
Air space enlargement induced by intratracheal elastase is augmented by prior depletion of lung hyaluronic acid.
Glucose depletion seems also able to augment the in vivo ability of MSCs to repair infarct myocardium [ 7].
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