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We here demonstrate for the first time that the initial site of Tau-seeding determines the behavioral outcomes, resulting in different behavioral outcomes depending on the initiation site.
However, we do not think that local ablation of a mother rotor is of clinical use, as multiple mechanisms of VF can occur in the same heart depending on the initiation procedure.
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The influence of bedding planes' occurrence mainly depends on the initiation position of the fractures, the influence increases with increasing the horizontal stress ratio and pore pressure.
The timing of the situation awareness updates depends on the initiation and duration of related tasks (e.g. monitoring, communication, coordination).
In programmed cell death, the ultimate fate of the cell depends on the initiation signal and the degree of assault, and the outcome is known.
The expression rates of luxI and luxR depend on the initiation rate of transcription, the speed of elongation, the length of the transcript, and the rate of translation and postmodification into functional proteins.
Then, we distinguished between two kinds of ORFs, depending on the translation initiation mechanism: leaderless ORFs and Shine-Dalgarno (SD) initiation ORFs (sdORFs).
Depending on the crack initiation time and environmental conditions, crack sealing varies from a few tens of years to a few thousand years.
We previously showed that the SPG4 gene synthesizes two isoforms of spastin (68 kDa and 60 kDa, respectively), depending on the alternative initiation of translation from two AUGs in the first exon [ 11].
Depending on the randomization allocation, initiation and discontinuation of antibiotics is encouraged or discouraged based on evidence-based guidelines or procalcitonin cut off ranges, respectively.
Taken together, our data indicate that prion-like seeding of Tau-aggregation along synaptic connections affects selective functional brain circuitries, thereby determining the behavioral dysfunction depending on the site of initiation of Tau-pathology.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com