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Depending on the developmental context, extrinsic signals or intrinsic cues control the correct orientation of the mitotic spindle.
Thus, in addition to its requirement for cell viability, Ras appears to mediate different biological roles depending on the developmental context and on the level of its expression.
Depending on the developmental context, two different types of overgrowth can be detected.
In Drosophila, depending on the developmental context, either dMib1 or dNeur is required for the activation of two Notch ligands, Delta and Serrate [10] [12].
These are selectively used depending on the developmental context [ 5].
This study provides an intriguing example of how the function and requirement for regulatory proteins and their corresponding signaling pathways can vary drastically depending on the developmental context and cell type.
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Thus, the relative functional contributions of E2F1 and E2F2 to gene expression and cell cycle control depends on the developmental context.
A common feature of lateral inhibition by NOTCH signalling throughout the animal kingdom is that mediates the binary decision of adjacent cells between two alternative fates, which depend on the developmental context [9], [17].
Interestingly, the function of Notch in the regulation of proliferation depends on the developmental context, because in the proximal and hinge regions of the wing discs the ectopic expression of Notch induces overgrowth (Go et al., 1998; Giraldez and Cohen, 2003; Baonza and Garcia-Bellido, 2000).
Their action results in different outcomes depending on the developmental stage, tissue and/or cellular context.
Identical temperatures yielded qualitatively different results depending on the developmental stage.
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