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The role of CXCL10 is rather complex, also depending on its action on different isoforms of the CXCR3 receptor.
Roles of noncanonical Wnt5a in human malignancies seem to mainly depend on its action on canonical Wnt/β-catenin pathway.
However, we believe that each lncRNA has to be considered on its own merits, depending on its mechanism of action and it is therefore not possible to define a set of general guidelines that would be applicable to all cases.
Based on the type and severity of acne, the selection of proper medication depending on its mechanism of action relating its ability to address one or more of the pathogenic factors is the major challenge allied with its treatment selection.
These results also indicate that CREB activity can both increase and reduce lipid stores in flies depending on its site of action.
We show that automated support strategy restores nominal performance after a performance drop is detected and takes the right course of action depending on its cause.
This has led to a model where the H2A.Z-mediated shift in nucleosome positioning at promoters may have a repressing or activating action depending on its occluding or permissive effect in allowing access to regulatory DNA sequence elements [ 76].
Our results showed that if GABAergic inhibitory control of presynaptic glutamate release in VTA-DA neurons was removed, the effect of morphine on the firing of VTA-DA neurons disappeared, indicating that the morphine-induced increase in VTA-DA neuron activity might mainly depend on its disinhibitory action on presynaptic glutamate release.
The toxic effect of a detergent depends on its mode of action, the toxicity of the active ingredient (surfactant) in relation to its chemical and physical structure and the response of the test organism (Ofojekwu et al. 1999).
The choice of the specific cytotoxin to be used in an ADC depends on its mechanism of action and the type of cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com