Rather, we think that the increased survival depends on complement perturbation and therefore on the interaction between FLIPr and C1q.
AQP4-IgG lesions are characterized by astrocyte damage followed by leukocyte infiltration that entirely depend on complement activation [ 5].
The K/BxN model is driven by immune complexes and depends on complement, Fc receptors, and innate immune cells, mainly neutrophils [ 35- 37].
As the effect was not observed upon injection of immune complexes containing F ab′ 2 fragments, the authors concluded that the effects observed depend on complement activation.
The humanized NC16A (NC16+/+) mice injected with anti-BP180NC16A autoantibodies develop BP, and the disease development depends on complement, mast cells and neutrophils (Fig. 1).
Some neutrophil activators depend on complement (calcium ionophore A23187), while others require opsonization (zymosan) and others, such as N-formyl-methionine-leucine-phenylalanine (fMLP), depend on specific protein receptors [ 35].
To identify whether the effect of C3 on cancer cells depends on complement activation, we used hC5 siRNA to knock down C5 gene expression in cancer cells and investigated its effect on tumor growth.
Others may include the 'danger signals' and/or cytokines [ 18] that favor initial T cell autoimmunization rather than tolerance, the strength of the primordial antibody response and of the consequent complement attack on myoid and epithelial cells [ 17, 19] which may depend on complement receptors and regulators as well as activated components, and may also amplify the infiltration.
The magnitude of its impact on growth, respectively biomass accumulation or carbon sequestration, depends on complementing conditions like former nutrient deficiencies, moisture and stand age.
While much interest and focus has been directed toward phloem-feeders like aphids and mealybugs, blood-feeders such as the Lone star tick (Amblyomma americanum), Glossina flies, and the human body louse (Pediculus humanus corporis) depend on obligate endosymbionts which complement their B-vitamin-deficient diets, and thus are required for growth and survival.
