By RT-qPCR, we confirmed that Ponatinib indeed dose- and time- dependently affected the expression of 6 BCLM-associated genes, including ANGPTL4, MMP1, PTGS2, TNC, LY6E and RARRES3 (Fig. 1F and 1G).
We assessed whether these compounds time and dose dependently affected the tumour cells.
Also, tea solids dose-dependently affect FMD when caffeine intake is kept constant [41].
Propofol can dose-dependently affect the EEG directly by an increase of slow waves.
Of note, not all parameters were dose-dependently affected.
The composition of the patients and the number of examinations were not equal for each of the treatment durations, and may have been time-dependently affected by candesartan monotherapy itself.
In vitro, pituitary cells from animals treated with BPA showed lower basal LH and dose-dependently affected GnRH-induced IP3 formation; the high dose also impaired GnRH-induced LH secretion.
Thus, GIRK activation state-dependently affected the slope of the tested cells, similarly to the lower temperature, even though the two interventions has largely opposite effects on the classical measures of cellular excitability.
Here we demonstrate in healthy individuals that increasing concentrations of CO2 dose dependently induce a negative affect and that this affect is semantically identical to panic, as defined in current psychiatric nosology.
The turnover rate of L-[C]DOPA is state-dependently modulated by drugs that affect dopaminergic systems and is thus also a measure of the functional state of the dopaminergic neurons [ 27- 29].
DEA/NO concentration dependently attenuated CSE activity but did not affect CBS activity.
