The pitch patterns, Pe[k, n], are smeared out over frequency using the level dependent spreading function.
The absence of stiffness dependent spreading and differentiation on PDMS, apparently contradictory to previous findings of cell differentiation dependence on substrate stiffness, can be explained by the ability of seeded cells to remodel the collagen layer present on viscoelastic PDMS, diminishing their sensitivity to substrate stiffness.
Moreover, there was an increase of pTDP-43 pathology in wider areas of the contralateral cortex over time (Fig. 3e h), indicating the time-dependent spread of TDP-43 pathology to sites distant from the injection.
Growth curves showed a gp48-dependent spread deficit similar to that seen on a wild-type background (Figure 3E).
infection, MHV-68 takes on acute virus replication in the lung, followed by B-cell-dependent spread of virus to the spleen and other lymphoid tissues.
However, the NA-dependent spread of the 1918 virus was not due to plasminogen recruitment and NA facilitating HA cleavage by the 1918 NA [19].
The distinct differences in host strain-dependent spread and replication of HSV-1 in the perineurial cell layer might support the hypothesis that the genetic properties of the perineurial cells could possibly have a key role in viral entry to the CNS and progression to HSE.
However, a nanotube-dependent spread may open new avenues in the development of antiviral drugs.
Finally, network-dependent spread could account for heterogeneity within a distinct diagnostic tauopathy.
In this study, we revealed that a progression-dependent spread of the tumor microenvironment to the shallow layer of the tumor tissue resulted in reduced bowel patency.
Network-dependent spread could explain this, if the initial tau aggregation was a stochastic event that was followed by deterministic spreading dependent on network connectivity.
