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Even if the smoking adjustments are not unreliable and do not bias ORs upward, positive results supporting the diesel-lung cancer hypothesis are still inconclusive because they are model dependent; significance depends on which model and lag period are used.
Therefore the presence and nature of the sulfur source must have a light dependent significance beyond just signaling the availability of a nutrient (Gremel et al., 2008).
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Instead, it relates a modulating signal with light-dependent significance, since induction still required the presence of an inducer.
Identical results were obtained with both sampling methods giving confidence in our results and strengthening the evidence for an ER-dependent significance of TSR.
Of the 8 expression clusters significantly co-localized under MPED assessment, only 2 were significant across all three thresholds under dichotomized distance enrichment (see "Supplemental Information" from [ 3]); the other 6 had threshold-dependent significance under dichotomized distance enrichment.
Both pro-inflammatory cytokines, IL-1β and IL-6, were significantly inhibited (P < 0.002, P < 0.04 respectively); the reduction was dose dependent and significance reached at 100 ng/ml of ephrin B2.
With some quantitative differences, PFC cells show similar coding of fixed and context-dependent behavioral significance.
The effects of nitrate were time-dependent, reaching significance after 6 days of differentiation (Additional file 2: Figure S2).
We report on the stage-dependent prognostic significance of chromosomal instability (CIN) and microsatellite instability (MSI) in a large consecutive series of colorectal carcinomas treated in one hospital with a defined catchment area.
The favorable prognostic value of EBER and p63, the treatment-dependent prognostic significance of Cyclin D1, as well as the independent prognostic value of ERCC1 and p-mTOR protein levels could be pointed as the most interesting ones.
Optimal models were determined using backwards stepwise regression, with the inclusion of a predictor variable dependent on the significance of Type III MS and Wald χ values.
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