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The alignment is evaluated using the sequence dependent score: SP - score = ∑ aligned residue a, b BLOSUM 62 a, b, (1).
To reduce false positives, especially for targets like GPCRs where almost all structures are similar (TM-score > 0.4), a sequence dependent score similar to the SP-score in Eq. (1) over the fr-TM-aligned residues is used instead of the TM-score.
c = p (VIPI × Dependent score) < 0.01.
The files containing translation dependent score matrices computed for several evolutionary distances can be downloaded at the same address.
We selected the best fitting model across different dependent score variables that yielded the smallest Akaike information criterion (AIC) value, since the set of the independent variables was identical for all dependent variables in all models.
The sum of scores from the 10 items provides guidance on whether the respondent engages in hazardous (score 8 15), harmful (score 16 19) or dependent (score ≥20) drinking behaviours, using cut-offs defined by WHO.
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Figure 3 Flowchart of two FINDSITE-based component approaches (A) FINDSITE filt (B) FINDSITE X. FINDSITEfilt [12] employs a heuristic structure-pocket alignment procedure and a sequence dependent scoring function to rank the holo templates in step (B) above.
Results: We present a profile-entropy dependent scoring function for low-homology protein threading.
In this present study, subjects who were severely nicotine dependent scored less in the PANSS negative symptoms.
In this simple form, the static quality and the query-dependent score from (24) have equal contributions, assuming each is between 0 and 1.
The query-dependent score normalization produces the smallest difference between MTWV and ATWV.
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