Sentence examples for dependent on variant from inspiring English sources

Their aetiology is complex, since although their genesis frequently lies in aberrant splicing, cell line and xenograft models most dependent on variant expression harbour rearrangements in the AR gene locus that preclude transcription of LBD coding exons (Li et al, 2011, 2012).

Even methodical selection, Darwin realized, is dependent on variants that arise without regard to human desire.

Recovery maximization from horizontal well completion is a challenge in the oil industry, which is dependent on variants viz: critical rate, length of horizontal section, offset from water oil contact (WOC), withdrawal rate.

Decreased or absent activation of CARD15 dependent pathways has previously been described for three CARD15 variants associated with CD [5], [16], [19], [25], and the response was shown to be dependent on one specific variant (SNP 13 1007fss) homozygote) causing less activation than the other two [14].

However, if it occurs only upon overexpression, it is dependent on histone variant incorporation (Fig. 3a).

This amino acid change is predicted to have a benign and damaging effect on the protein by PolyPhen-2, 21 dependent on the variant protein.

31 However, a different group recently showed that when Bak protein as opposed to Bak BH3 peptide 31 was used, Bcl-2 could bind Bak with similar or better affinity than Bcl-xL, although this was somewhat dependent on the variant of Bcl-2, 32 so the in vivo specificity of Bak for Mcl-1 is unclear.

The sensitivity of other cancer-related tyrosine kinase inhibitors varies according to the specific receptor mutations, resulting in mutation-specific binding affinities; thus, the development of MET tyrosine kinase inhibitors has been designed to have high-affinity binding dependent on the variant, in order to decrease resistance to these agents [ 25].

Such effects could be dependent on polymorphic variants of GCKR or G6PC2 genes, both of which were shown to affect lipid and glucose metabolism [ 16].

Analyzing this subset further by taking away those carrying the SE or PTPN22*620W allele showed an even stronger association with the MBL-high genotype, indicating that the pathogenic mechanisms involving MBL are not dependent on these variants.

Given the many HPV subtypes, and the transforming function being dependent on sequence variants and integration events, establishing the oncogenic potential in a given HPV-infected cancer is a complex task.