Thus, EBV transits from being dependent on the cellular replication machinery during latency to commandeering both that machinery and nuclear structure for its own reproductive needs.
This mutant (swi3-E39) also had defects in recovery of broken replication forks but not in resumption of arrested forks (Figure 5), the latter of which is dependent on the Cds1-dependent replication checkpoint.
The expression of the L genes is partially (γ1, leaky L genes) or completely (γ2, true L genes) dependent on the viral DNA replication.
Type II fibers in our study had a higher degree of atrophy than did type I fibers, despite the fact that the former appeared to be less dependent on mtDNA replication than the latter, as evidenced by a lesser degree of mtDNA depletion.
We next assessed whether the effect of Trx80 on replication of intracellular pathogens was dependent on the site of bacterial replication, and we therefore have investigated the ability of TAMs to control infection with Brucella abortus, a Gram negative bacterium that replicates in the ER of infected cells.
These results also indicate that the development of a protective immune response is dependent on detectable replication of the LPAI virus.
The ISG response was induced with a delayed kinetics, compared to virus infections, and was dependent on bacterial replication and the bacterial type III secretion system (T3SS).
In the budding yeast, HR has a dominant role in virtually every type of DSB repair, but is not dependent on DNA replication or the presence of duplicated chromatids, but rather on Clb-CDK activity, which is required to carry out end resection, one of the earliest stages of the HR process [172], [173].
In this work we demonstrate that expression of ISGs during infection with C. pneumoniae is mediated by nucleotide-sensing PRRs residing in endosomes and the cytoplasm, and this response is induced through signalling by TBK1/IKKε and is dependent on bacterial replication and the bacterial type III secretion system.
