Claims of functionality of alternative transcripts should depend on observation of phenotypes specifically dependent on the integrity of the proposed coding region of the alternative isoforms.
It may be that this latter form of integrative function is more dependent on the integrity of axonal processes and on the relative timing and intensity of feedforward and feedback signals, and so Arc reporting of signal in the hippocampus is inherently more sensitive to subtle effects compared to visual cortical responses.
The safety of the future CO2 geological storage is largely dependent on the integrity of existing surrounding wells.
Furthermore, the pressure effects on prion protein structure appear to be strongly dependent on the integrity of the disulfide bond.
Vasodilation induced by both derivatives is likely to be mediated by a direct effect on smooth muscle because it was not dependent on the integrity of vascular endothelium.
Inhibition of ligand-activated EGFR signaling by E-cadherin is hereby dependent on the integrity of the extracellular domains of E-cadherin and independent of β-catenin or p120ctn binding [26].
Mycobacteria's ability to survive and cause disease is dependent on the integrity of this lipid-rich layer referred to as myco-membrane (Bhatt et al., 2007; Takayama et al., 2005).
Physical asset performance management is dependent on the integrity of the asset being sustained for the life of the investment, in order to perform at design capacity without a major loss of primary containment (LOPC).
The ability of menisci to prevent osteoarthritis (OA) is dependent on the integrity of the complex meniscal entheses, the attachments of the menisci to the underlying subchondral bone (SB).
We demonstrate here that administration of GI264879A to rats causes a significant decrease in food intake and body weight partly through a mechanism dependent on the integrity of the vagus nerve.
The structural integrity of traditional FRP components in corrosive environments is usually dependent on the integrity of a corrosion-resistant barrier, such as a resin-rich layer containing corrosion resistant glass fibers.
