It may be brittle and rather dependent on Ed Miliband sustaining his poll lead.
"Nurse Betty" is as much a triumph for Mr. LaBute as it is for its cast, because its success is so dependent on its sustaining a precarious balance between humor and pathos, realism and fantasy.
Figure 3D shows that in control CTLs, the activity of mTORC1 was strictly dependent on cells sustaining high levels of glucose uptake as even a switch into 1 mM glucose inactivated mTORC1.
Abnormal Treg cell homeostasis and function did not reflect the involvement of p56Lck in CD4 function because these effects were not observed when CD4 expression was inactivated by Ox40-cre.The results make clear multiple aspects of Treg cell homeostasis and phenotype that are dependent on a sustained capacity to signal through the TCR.
A successful pharmacotherapeutic treatment is dependent on a sustained and steady effect on the ORs and requires a tailored dose regimen.
This appears to be a highly dynamic process dependent on the sustained rapid synthesis and degradation of Arc protein [ 17, 19, 54, 55].
The obvious mechanisms of chronic airway inflammation in asthma are incompletely known but are considered to be dependent on the sustained infiltration and activation of numerous inflammatory cells including eosinophils, neutrophils, lymphocytes, and macrophages, followed by synthesis and release of a variety of pro-inflammatory mediators and cytokines [ 31].
Contrary to miRNA-mediated posttranscriptional silencing, which is transient and dependent on the sustained presence of the effector miRNA, TGS targets promoter regions and triggers heterochromatin formation by inducing DNA and histone methylation (H3K27me3 and H3K9me2), which leads to long-term silencing.
Taking advantage of such policy windows may enhance uptake, although long term sustainability may be dependent on resources and sustaining the enthusiasm after the policy window is over [ 14].
The American conscience has always been troubled by its relationship to genocide and slavery and, as Grandin points out, Melville throughout his writing life examined the anomalies by which people lived, dependent on death to sustain life and on slavery to sustain freedom.
