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The biphasic nature of HPV has been recognized for many years, and the initial Phase 1 constriction differs mechanistically from that during the sustained Phase 2. Although both phases are associated with an elevation of smooth muscle [Ca2+]i, this is very small in Phase 2 and critically dependent on release from ryanodine-sensitive stores, with a reduced or absent dependence on Ca2+ entry.
Furthermore the inhibitory effects of hemozoin were not dependent on release of pro-inflammatory mediators from the macrophage.
Additionally, clustering of LFA-1 has been shown to be dependent on release of LFA-1 from the actin cytoskeleton, since cytochalasin D treatment results in increased lateral mobility of LFA-1 in resting cells [12].
SRF activation is dependent on release of a parasite-derived secreted factor that is likely Toxoplasma specific since SRF was not activated by the closely related parasite Neospora caninum.
The apoptotic response is dependent on release of cytochrome C from the mitochondria through activation or up-regulation of the pro-apoptotic members of the Bcl-2 family [10], [12], [13], [14].
Significantly, we observed that the branch formation process is strictly dependent on release of diVCA from the filament-bound Arp2/3-diVCA complex.
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Attending ARF, the Asean regional forum in Phuket, US secretary of state Hillary Clinton informed the Burmese delegation that any US offer to improve relations is dependent on releasing Suu Kyi and other political prisoners.
In this situation, when the Calvin cycle has stopped and can no longer function as a sink for carbon and energy, the system is in a reduced state and the cells will be dependent on releasing electrons from the system in order to prevent oxidative damage.
Releases in this experiment were proportional: daily estimates of adult male recruitment for each cage were used to calculate a daily male release number for that cage, dependent on the release rate pre-determined for that treatment.
The hyperCCKemia in patients who had undergone colectomy is consequently not only dependent on CCK release, but may also depend on reduced clearance.
Note, the implementation of this feedback does not depend on the underlying mechanism being release of serotonin, so the model's predictions are not dependent on serotonin release per se.
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CEO of Professional Science Editing for Scientists @ prosciediting.com