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Activation of CD4+ T cells is dependent on presentation of antigen by MHC-II molecules on APC.
As the KO phenotypes were dependent on presentation of sensory stimulus, RAGE may play an active role in sensory organs or the brain.
Since CTL mediated cytotoxicity is dependent on presentation of antigens through an intact APM, we investigated the status of the APM in the EAC cell lines and EAC patient biopsy specimens.
Patients in the sclerotic class who were dialysis dependent on presentation had no significant response to therapy.
Whereas clonal deletion of CD4+ T cells seems to be primarily dependent on presentation of endocytosed structures displayed in the thymus by thymic DC's, central tolerance at the level of CD8+ T cells is established predominantly via presentation of internal self epitopes on the MHC-I molecules on thymic epithelial cells, although thymic DC's may also participate in this reaction [ 20].
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T cell activation was dependent on the presentation of WTA on MHC II, since inhibitors of MHC II-dependent presentation and antibodies to MHC II significantly reduced T cell proliferation.
The efficacy of such vaccines is usually dependent on adequate presentation and delivery, namely, carrier/adjuvant technology.
Activation of naïve T cells is dependent on antigen presentation by dendritic cells (DCs) in lymphoid tissues.
The development of Th17 cells from naïve T cells is dependent on antigen presentation, co-stimulatory stimulation and a specific cytokine milieu (e.g.: IL-1β, IL-6, TGF-β) with IL-23 production being important for the maintenance of Th17 cells [41].
The management of diagnosed PCa is crucially dependent on the presentation of the disease [ 4].
The acceptance or rejection of the LNT theory is also not dependent on the presentation of other, putatively superior, alternative hypotheses (e.g. hormesis, linear threshold models).
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