Kinase activation of CDC7 is dependent on expression of DBF4, and both genes are highly expressed in cancer [ 55].
As mentioned by Piasecha et al. [ 35], both Euclidean distance and Pearson's correlation coefficient of expression intensities are dependent on expression tissue specificity, and underestimate expression divergence of specifically expressed genes, because many silent or low expressed tissues cause similar overall expression between tissue specifically expressed homologous genes.
Since the overlap is in part dependent on expression (eQTL and ASE are easier to detect for highly expressed genes), we also assessed agreement on the direction of bias (B6 vs BTBR Figuree 2b).
One compound, termed 3144, was found to bind to RAS proteins using microscale thermophoresis, nuclear magnetic resonance spectroscopy, and isothermal titration calorimetry and to exhibit lethality in cells partially dependent on expression of RAS proteins.
MYC/Max binding to promoter sites is dependent on expression level, with more sites occupied at higher MYC levels [58].
Others describe mortality between 21 70% dependent on expression levels in different APPswe lines at 12 months of age [44].
In facts, because the A averaging methods minimizes the weight of single data, A-based measures are expected to be more dependent on expression breadth [2].
Thus, in both BMDMs and immortalized macrophage-like cell lines, LT causes relocalization of AO that is dependent on expression of an LT-responsive Nlrp1b allele.
We have demonstrated that PDHCs can promote autoimmune disease in mice and that this process is dependent on expression of TLR2 [2].
CD38−/− mice show enhanced development of autoimmune diabetes in NOD/Lt and this effect is dependent on expression of ART2 [36].
Moreover, plasmid replication is dependent on expression of each of the viral genes known to be required for genome replication [43].
