Sentence examples for dependent on elevated from inspiring English sources

Decidualisation can also be induced in vitro in endometrial fibroblast-like stromal cells where the process is also dependent on elevated intracellular cAMP levels.

Prior to differentiation, Tsc2−/− MEFs express greatly elevated levels of both the PPARγ protein (Figure 4E) and transcript (Figure 4F), and these are dependent on elevated mTORC1 signaling, as indicated by their sensitivity to rapamycin.

Our results suggest that UPRmt activation and lifespan elongation in the nduf-7 (et19 ) mutant are dependent on elevated ROS, which may act upstream of ATFS-1.

This is associated with inhibition of AKT activity dependent on elevated PTEN, and with altered cell motility, actin rearrangement, and increased formation of adherens junctions.

We demonstrate that this recruitment is dependent on elevated oxidized glutathione levels, providing a novel protective mechanism for GDAP1-family members acting as sensors for altered cellular redox environment.

Our data would suggest that the benefit with PD 0332991 might be extended beyond that 25%, since the benefit was not dependent on elevated cyclin D1 alone in the HER2-amplified cell lines.

The sporulation phenotype appears to be dependent on the elevated calcium concentration, a so far undefined component present in casein and a low pH.

We find that, despite severe insulin resistance and the absence of Akt signaling, TSC2-deficient mouse embryo fibroblasts and 3T3-L1 pre-adipocytes display enhanced adipocyte differentiation that is dependent on the elevated mTORC1 activity in these cells.

Given the previous studies demonstrating that rapamycin could block adipocyte differentiation [11] [16], we hypothesized that the enhanced adipogenesis phenotype of Tsc2−/− MEFs would be dependent on the elevated mTORC1 activity in these cells.

The increase in the fraction of IRES-dependent translation was dependent upon AMPK activity (Figure 7 and Figure 8), and the increased levels of AMPK in the transformed cells were dependent on the elevated c-Src activity in these cells (Figure 6B,C), rather than on the AMP ATP ratio in the cells.

Importantly, we show that BRCA1-deficient cancer cells are selectively dependent on their elevated EZH2 levels.