Strain surveys demonstrated that sensitivity to morphine is to a great degree dependent on genetic determinants.
This baseline risk is multiplied by a term exp(β x), dependent on the determinants x, which are different between individuals.
The effect of dsx on shaping dimorphic tissues can be dependent on spatial determinants as was discovered in examining the sex-specific development of gustatory sense organs (GSOs) in the foreleg of D. melanogaster [ 66].
Indeed, insertion site selection during in vitro transduction could be driven by tethering of transcription factors (TF) to specific regions according to TF binding sites location (Felice et al, 2009) and seems dependent on cellular determinants as well as on vector design (Lewinski et al, 2006).
Together, these data suggest that the mitogenic activity of DNA is dependent on sequence-specific determinants that can be presented by synthetic DNA duplexes as well as bacterial ss and dsDNA.
The causal mechanisms behind this are unclear but may be dependent on specific contextual determinants.
These data suggest that the importance of TSR in breast cancer may be dependent on key molecular determinants of tumour subtype of which ER status is pre-eminent.
The lysosomal localization of AGA is dependent on a conformational determinant that mediates its interaction with the phosphotransferase that generates the M6P signal, a prerequisite for the lysosomal targeting of AGA21.
MECA-79 is an antibody that recognizes 6-sulfo sLex, a sulfation dependent determinant on L-selectin ligands that overlaps with the ligands' recognition epitope (Pablos et al., 2005).
No matter how important some health issues might be, global health is dependent on a wide range of determinants and many other priority issues - for example education, water, food, energy, and environment -- which will impact on any heath goals we might consider.
