Trafficking of IMC‐targeted vesicles is dependent on the highly conserved, apicomplexan‐specific, small GTPase TgRab11b (Agop‐Nersesian et al., 2010).
Induction of peptide release by class-1 RFs in general and e/aRF1 in particular, is completely dependent on a highly conserved GGQ motif in the M domain of the protein [ 12, 50- 53] (fig. 1B, fig. 2A).
In this regard, it is important to point out that the complexes (homologous and heterologous) form in vitro, and are dependent on the strictly conserved tryptophan residue (see Chatterjee et al., 2012).
Furthermore, using a silent mutant 1 220 truncated LAMR construct, homologous to the A. fulgidus S2 ribosomal protein and devoid of the C-terminal 75 residues, we clarified whether cell viability in HT1080 cells is dependent on the highly conserved ribosomal functions of LAMR.
Mutation of the highly conserved HPD tripeptide of Hsp40 (Hsp40HPdidAA) did not abolish binding to CSPα, indicating that CSPα/Hsp40 association is not dependent on this conserved motif.
These approaches are not dependent on the identification of conserved RNA sequences or secondary structures, and therefore are well-suited for the discovery of unstructured or poorly-conserved ncRNAs.
Waterbird Conservation for the Americas is an international partnership, working regionally, to conserve birds dependent on aquatic habitats.
Thus, the structural homogeneity of the 9 + 2 axoneme seems to be dependent on a relatively few evolutionarily conserved proteins and masks considerable organism-specific elaborations that go beyond the presence of obvious extra-axonemal structures.
In the SSU, several subunits identified as universally conserved are dependent on bacterial ribosomal proteins S16, S6, and S18 for binding [10].
The non-conventional splicing of Hac1 (yeasts) and XBP1 (metazoans) mRNA, encoding orthologous UPR transcription activators, is conserved and dependent on Ire1, an ER membrane-resident kinase/endoribonuclease.
It comprises a catalytic core, composed of the three mtDNA-encoded subunits, whose functional assembly is dependent on a set of phylogenetically conserved nuclear-coded subunits (Cox4, Cox5a, Cox5b, Cox6b, Cox6c, probably Cox7c, Cox8, using the mouse nomenclature) required to produce, via a stepwise assembly pathway, a membrane-bound sub-complex with enzymatic activity (12, 13).
