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STC1 gene induction by PACAP was dependent on cAMP and ERK1/2, independently of PKA.
Third, retinal activity is critical for mediating RGC survival, a process that is dependent on cAMP [6], [7].
Other signaling pathways dependent on cAMP, but independent of PKA, have been characterized and can be activated following A2b stimulation, including cAMP-stimulated GDP exchange factor (EPAC1 and EPAC2) pathways [27].
Repetitive exposures to nicotine have also been shown to induce a hyper-responsiveness that is dependent on cAMP signalling and known to be sensitive to the dnc mutation [33].
In peripheral tissues, PKA phosphorylates TSPO, and this phosphorylation is dependent on cAMP (34).
The response is also largely dependent on cAMP production, as well as a functional TOR pathway (Slattery et al. 2008).
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The decision of initiating culmination is also dependent on extracellular cAMP, that activates the STATa transcription factor at the tip organiser region, in the anterior of the slug, initiating a regulatory cascade that proceeds through activation of the CudA transcription factor [16], [17] and the tip-organiser-specific expression of their targets genes, such as expl7[18].
Overall, these data suggest that the anti-proliferative effect of propionate is partially dependent on the cAMP level.
Expression of the unique subunit of this transporter, xCT, is dependent on a cAMP response element in the promoter of its gene.
As is true for many of the effects of β-agonists in the body, the stimulation of AFC is dependent on a cAMP intracellular signaling mechanism, which in turn activates various ion transporters [ 18].
In addition, we observed that expression of Hcp was dependent on the cAMP-CRP global transcriptional regulatory complex and required the RpoN sigma factor.
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