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We remain too dependent on burden of disease modelling based on intelligent, but not sufficiently empirical real time data at country level on disease and risk factor dynamics.
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Sensitivity of India ink microscopy was the lowest (86%) of any test and highly dependent on fungal burden.
Fenton [ 41] observed that the outcomes of coinfection are highly dependent on helminth burden among other factors.
This suggests that the reduction in osteoclast number is dependent on tumor burden, but is not sufficient to increase bone mass.
These observations suggest that efficacy of T-DM1 is largely dependent on tumour burden of the JIMT-1 xenograft model used.
In the present study, there was only a weak relationship between albumin concentrations and tumour volume, and therefore the prognostic value of hypoalbuminaemia would not appear to be primarily dependent on tumour burden.
Unlike other solid malignancies, the prognosis of HCC is not solely dependent on tumour burden but is also adversely influenced by impaired liver function secondary to the underlying pathogenic condition (Tandon and Garcia-Tsao, 2009).
Involvement of the testis is usually accompanied by cancer spreading to other sites, rarely affecting survival that remains largely dependent on the burden and aggressiveness of the underlying disease and the vital importance of involved organs.
Moreover, prognosis of HCC, which is considered a multifactorial malignancy, is not solely dependent on tumour burden but is also adversely influenced by impaired liver function secondary to the underlying pathogenic condition [ 1, 10, 16].
aTumor t50 was reported; bmetastasis/tumor appearance but not incidence was reported; clung metastasis in all Plg-/ mice analyzed versus 56% in control mice; metastasis was dependent on tumor burden.
To demonstrate whether the observed inhibition of ascites formation was attributable to reduced vascular permeability mediated by Ang-1 and not solely dependent on tumour burden, we used the Miles in vivo permeability assay to determine the direct effect of Ang-1 on vascular permeability.
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