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This second phase of diversification is antigen dependent, occurs in the activated B-cells, and arises from three mechanisms: somatic mutations, gene conversion, and class-switching [ 4– 6].
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Logistic regression applies maximum likelihood estimation after transforming the dependent into a logit variable (the natural log of the odds of the dependent occurring or not).
However, this potentially, synergistic relationship is drug-sequence dependent, occurring only when cells are treated with letrozole, followed by ZA.
Similar as in the case of mortality hazard this deleterious phenotype is age dependent occurring in middle aged and old flies but not young per mutants.
First, the function of Hh signaling in human cancers may be context dependent, occurring in some tissues or cell lines but not in others.
It was highly growth phase dependent, occurring only after stationary phase had been reached and not during log-phase growth, indicating the importance of nonpermissive growth conditions for this persistence phenomenon.
Most of the adverse effects due to PB are dose dependent, occur early after treatment initiation or dose increase and generally disappear or decrease in the subsequent weeks due to development of pharmacokinetic and pharmacodynamic tolerance [ 35, 121] (Table 1).
For instance, induction by rapamycin of the RTG responsive gene, CIT2, is nitrogen-source dependent, occurring in ammonia or glutamine but not proline or glutamate grown cells (Tate and Cooper 2003).
Serial production of simultaneous dependents occurs in the vast majority of bird species and, in most, leads to the well-studied phenomenon known as hatching asynchrony [for reviews, see 4] [6].
This phenotype was ligand-dependent, occurring with IGF-I or supraphysiological doses of insulin, and did not occur in cells over-expressing the kinase-dead receptor.
Hence, unlike the contextual interaction between novelty and reward (Fig. 5), this aspect of the exploration bonus may be strongly task-dependent occurring only when subjects can attend to reward contingencies without having to assess novelty.
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