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The effects were found to be dose dependent, mild in the lower doses and marked in higher doses.
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Few studies have examined BP and CPAP use in patients with positional-dependent mild OSA.
The results demonstrated dose-dependent, mild, and transient EGFR decrease upon Photofrin-PDT (Supplementary Figure 4).
Mice overexpressing human TDP-43WT develop no overt physical or pathological phenotype, while those overexpressing mutant human TDP-43Q331K develop an age-dependent mild motor and pathological phenotype.
These include a transient reduction in heart rate and atrioventricular conduction on treatment initiation, a dose-dependent mild increase in airway resistance, macular edema, a mild increase in blood pressure, and asymptomatic elevation in serum levels of hepatic transaminases.
Preliminary results obtained from four independent experiments seem to indicate that exposure of maturing DCs to spermine slightly promotes their maturation, as assessed by a dose-dependent mild increase of DC expression of CD83 – at levels similar to those observed in vivo – and of CD40.
Consistent with the structural mitochondrial abnormalities in aged flies, iPLA2-VIA −/− flies showed an age-dependent, mild sensitivity at Day 15 to hydrogen peroxide and, more so, to paraquat (Fig. 4B and C) that was not consistently present in younger 7-day-old flies (data not shown).
An efficient numerical model based on the time-dependent mild-slope equation is presented in this paper for the estimation of wave deformation across the surf zone.
This paper adopts the finite-volume method with adequate numerical algorithms for computing the wave transformation based on the hyperbolic time-dependent mild-slope equations involving wave breaking.
The aldehyde-modified cellulose derivatives showed dose-dependent mild-to-moderate cytotoxicity to mesothelial cells and macrophages in vitro, but all were biocompatible in the murine peritoneum, causing no adhesions for 3 weeks.
Id. at 3. The most prominent findings were scattered atrophic myofibers that were mostly type one oxidative phosphorylation dependent myofibers, mild increase in lipid in selected myofibers, and occasional myofiber with reduced cytochrome c oxidase activity.
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