SAKI, however, is determined by a complex and highly treatment-dependent interplay between inflammation, microcirculatory dysfunction, bioenergetic failure, and tubular cell adaptation to injury [3].
This study isolated a mas (More Axillary Shoots) mutant, which was identified as an allele of the mitochondrial AAA-protease AtFtSH4, and characterized the function of the FtSH4 gene in regulating plant development by mediating the peroxidase-dependent interplay between hydrogen peroxide (H2O2) and auxin homeostasis.
It takes into account the time-dependent interplay of these processes, as affected by ongoing vaccination, all determining the ultimate clinical outcome.
The objective of the present work has been to quantitatively characterize the time-dependent interplay between several immune subpopulations, and in particular CD4+CD25−, CD4+CD25+Foxp3+ and CD8+CD28−Foxp3+ cells, under tolerogenic conditions.
The phenotypes elicited and the context-dependent interplay of the H3-K56 and -S57 point mutations that mimic their respective modification states suggest that serine 57 phosphorylation promotes a nucleosomal transaction when lysine 56 is acetylated.
While single gene mutations can occasionally trigger an oncogenic state, it is more often the context-dependent interplay between genes that causes or modulates cancerous growth.
A time-dependent interplay between IL-2 and IL-10 levels has been noted following BCG induction and repeated booster vaccinations [53].
To add weight to these claims and as a further demonstration of the utility of our benchmark technique, we have shown the results of investigating two network-based heuristics, finding that they are not adequate in describing the complex frequency-dependent interplay in our model and may give misleading results.
Since the rates of reactions and the concentrations of species may effectively (and dynamically) alter the topology of the network, it is not surprising that it is difficult to encapsulate the subtle non-linear frequency-dependent interplay when these are excluded.
However, none of the methods estimating DNs or TDNs integrates functional information, such as GOBPs, during the network inference such that the inferred TDNs can represent directly temporal transition of differentially regulated GOBPs and time-dependent interplays between the GOBPs, thereby facilitating functional interpretation of the TDNs.
