We use a well-known distance-dependent duration model obtained by Atkinson and Boore (1995).
The essential aspects of this theory is described in Appendix A. A computer code (Boore, 2000) was therefore used in this study, which demands several input parameters including the seismic source spectrum, a crustal attenuation function and a distance-dependent duration function.
At 10, 25, and 100 mg twice daily, with or without foods, vildagliptin deeply inhibits DPP-4 (>90%), with linear pharmacokinetics and a dose-dependent duration of inhibition.
When adjusted for age, gender, CCI score and time-dependent duration of metformin use (Model 2), great reductions in cancer risk for metformin users are seen for total cancer, esophageal, liver, and pancreatic cancer (HRs, 0.13, 0.44, 0.06, and 0.15, respectively) though esophageal and CRC are not significant.
However if spring, summer, and autumn temperatures are too low, the temperature-dependent duration of development from one life stage to another becomes too long and the probability that a larva survives to be a reproducing adult falls below unity beyond a certain northern latitudinal limit (Ogden et al. 2005).
In particular, the wet phase is modeled as a rectangular pulse process with dependent random duration and intensity; the global dependence structure is described using multidimensional copulas.
Toxic effects of Al were dependent on duration of Al exposure, concentration of Al, and pH.
The medial lateral asymmetry of the wear does not appear to be significantly dependent on duration, however.
Parathyroid hormone (PTH) affects each arm of skeletal remodeling, with net anabolic or catabolic effects dependent upon duration of exposure.
