Although recent studies have shed light on the context-dependent, diverse physiological roles of MELK and its involvement in various signaling pathways, MELK's functions and regulatory mechanisms are just starting to be understood.
Taken together, these results suggest that host pulmonary CMI responses to the ts cna1 mutant that is eventually eliminated from the host without the induction of IFN-γ appear to be dose-dependent, diverse, and require further stimulation to induce C. neoformans-specific Th1-type cytokine responses to resolve subsequent experimental pulmonary cryptococcal infections.
ERK regulates the latent process in a transcription-dependent manner, as indicated by the microarray assay (see Table S1), whereas ERK regulates the extension process in a transcription-independent manner (Figure 5A), indicating context-dependent, diverse functions of ERK for cell differentiation.
Interestingly, inactivating mutations of merlin seem to have tissue-dependent diverse effects.
The selection of the photovoltaic system is dependent on diverse factors like cost, efficiency, complexity, technology and array dependency.
DiCE further extends these ideas by emphasizing that the processes of validation should be dependent on diverse evidence, because this better addresses the type I/type II error problem, as well as other recognized and unrecognized weaknesses of omic analyses.
Such an enormous diversity of roles is, of course, dependent on a diverse and complex society.
The performance of enzymatic saccharification is one of the foremost limiting factors which may strongly be dependent on the diverse species, complex chemical compositions, and structural characteristics of the feedstock materials.
The relationship between a medical specialty or condition and its associated research output, with respect to volume and 'quality', is complex and may be dependent on such diverse influences as funding, socio-political influence and disease causation [18].
Due to the heterogeneous study setting we are dependent on the diverse working methods of the participating healthcare providers.
Admi and Shaham [ 39] showed that the information young people needed was diverse, dependent on age, and what seemed appropriate and important to them at different stages in their development varied over time.
