This is 8-fold weaker than observed by FDS-SV, highlighting commonly observed (but protein dependent) discrepancies of affinities for surface-immobilized molecules versus solution affinities.
Moreover, the observed concentration-dependent discrepancy was more pronounced at late time points rather than the initial stages of hydrolysis when soluble sugars were observed.
Separate analyses of neonates, children and adults demonstrate significant age-dependent discrepancies in both basal and septic levels of circulating soluble adhesion molecules.
Such cell-dependent discrepancies of MRP5 inhibition were previously observed in other cell lines and are probably due to different MRP5 copy numbers per cell [ 43].
Country-dependent discrepancies in recruitment methods cannot be ruled out, and the survey was designed to encompass various scenarios of clinical practice, leading to some restriction in choice of responses.
It may be argued that these biases cannot be generalized across the entire visual field because the data were averaged across different visual quadrants; it is likely that some quadrant-dependent discrepancies exist (Van Essen et al. 1984).
In addition, frataxin measurements in compound heterozygotes for a single expanded GAA repeat and a point mutation depend on the exact mutation, with most mutations leading to decreased levels, others retaining frataxin immunoreactivity, and some leading to tissue-dependent discrepancies.
Given the fact that the activity of Sirt3 can be peptide sequence-dependent, this discrepancy may be caused by the different H3K9Cr peptide substrates used in Denu's and this study, which consisted of amino acid residues 5 13 and 1 15 of histone H3, respectively.
Epistatic effects were evaluated, ultimately, according to an intuitive fitness criterion represented by a mathematical function, being this dependent on phenotypic discrepancies between mutant and reference spatio-temporal expression trajectories.
Apart from our observations of target-specific differences in the HIV-1 latency models, a couple of groups have showed that cell line dependent and model-specific discrepancy should exist and differentially affect the mechanism inducing HIV-1 latency [ 29, 30].
While such discrepancies appear dependent on model, species, stage of disease and particularly on the degree of proteasome inhibition [25], these controversies indicate that better knowledge of mechanisms underlying effects of the proteasome, as well as proteasome inhibitors, in vascular cells is important in order to provide rational advances.
