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Model systems are ideal for interrogating metabolic questions in a tissue dependent context.
In this volatile, resource-poor and dependent context, health research has been conducted since 1976.
We propose a system of categorizing epigenetic phenomena as germline dependent, context dependent, or both, taking into consideration whether effects are general or specific (Table 2).
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Our studies reveal the signal-dependent context of HuR's cellular activities in thymocytes and its importance in the generation of a physiological T cell pool.
In a similar vein, Kim et al. reported that E-cadherin regulates Yap exclusion from the nucleus in a cell-density-dependent context [103].
A typical enrollment session in a speaker-dependent context requires only a few sample utterances to train a voice-tag HMM that captures both the speech abstraction and the speaker characteristics.
Six5−/−, Dmpk−/− and Mbnl1−/− mice show no deficits in hippocampus-dependent context fear conditioning (Figure 3Ai, Bi and Ci, respectively).
To determine whether SR proteins bound to the constitutive exons 22 and 24 could also activate splicing in an enhancer-dependent context, we cloned different regions of the two exons in the Dpy2 pre-mRNA.
Under the same conditions, myristoylation deficient G2A mutants were not present in membrane fractions regardless of whether they were expressed in a Rev-dependent or PRE-dependent context, consistent with previous reports [23] [25].
Further experiments are needed to determine whether Hdac1 represses the expression of these genes in a NuRD-dependent context.
These branches of the cycle need to be further investigated in a cell- and tissue-dependent context.
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