The phase-dependent consequences of topotecan treatment upon mitosis and apoptosis were measured without the confounding effects of cell synchronization or metabolic inhibition.
Moreover, the exposure to multi-generational stress in F1-SS and F2-SSS rats indicates that prenatal stress has cumulative, context-dependent consequences.
This suggests that MVO and IMH are not just separate entities, but rather ischaemia-dependent consequences of severely injured microvasculature in larger infarcts.
As well as being capable of simulating the temperature-dependent consequences of removing Su(dx) or dx function, the model was supported by verification of several remarkable predictions regarding unusual context-dependent genetic interactions between the two genes.
Since F is autocorrelated in time, the conditional probability P(F ′| F) gives the probability of having food availability F ′ in the next month if the current level is F. Optimization approaches rely on a static fitness measure, which is valid for populations experiencing simple density-dependent processes but means that frequency-dependent consequences on fitness cannot be included.
Thus, flagellum detachment was a secondary, time-dependent consequence of CaM RNAi, and coincided with the loss of normal trypomastigote morphology, thereby linking the presence of PFR architecture with maintenance of cell form, as well as cell motility.
There was one potential size-dependent consequence of nano-Se on scavenging free radicals: small size and medium size had similar effects and were both better than the large size [27].
Sadler and colleagues have pioneered the use of ethanol exposure in zebrafish larvae to elicit the most common form of human liver damage; consistent with mammals, hepatic fat accumulation occurs as a direct and dose-dependent consequence of alcohol intake (Howarth et al., 2011).
The loss of intestinal mass phenotype was proportional to the percentage of the diet composed of CDD, a result consistent with the possibility that the phenotype resulted from loss of a nutrient that was limiting in chow, or that it was a dose-dependent consequence of a component of CDD (Fig. 4, A C).
