Sentence examples for dependent bioavailability from inspiring English sources
A 75% artemether-lumefantrine dose increase (assuming a dose dependent bioavailability) would result in adequate exposures.
A 250% increase in dose (assuming a dose dependent bioavailability) would be required to achieve exposures similar to those following a standard artemether-lumefantrine antimalarial treatment without concomitant HIV treatment.
The pharmacokinetics of rifampicin are known to vary from study to study and the concentrations reported by Goutelle et al. 5 were lower than those reported by Ziglam et al. 43 Dose dependent bioavailability, auto-induction effects that occur on multiple dosing, and inhibition and induction effects on drug metabolizing enzymes and transporters all contribute to this interstudy variability.
Objective: To determine whether aminopeptidase N (APN) regulates the cycle-dependent bioavailability of interleukin-8 (IL-8) in the endometrium.
The final pharmacokinetic model was a linear two-compartment model with first-order absorption, an absorption lagtime, and dose-dependent bioavailability.
However, this model was used to successfully capture the observed dose-dependent bioavailability of rituximab.
I also showed that nanomaterials have salinity-dependent bioavailability and toxic effects.
Further investigations revealed that the antibacterial activity of BY07 and CB07 mineral mixtures is related to the pH-dependent bioavailability of toxic metal ions in a low pH environment [ 5].
Since the therapeutic window of these drugs is relatively small, they can "exhibit limited or erratic absorption, formulation-dependent bioavailability and intra-patient pharmacokinetic variability that requires blood-level monitoring" [ 12].
Dihydroartemisinin-piperaquine (DP) is a potential alternative; it can be taken once a day, does not have food-dependent bioavailability, and can be produced for a lower cost than AL.
Studies in which midazolam was not administered intravenously were also excluded as clearance is dependent on bioavailability if administered orally or rectally.
