Or, if there is no fixed place of business, is the trade carried on through a dependent agent?
This paper presents the introduction of context-dependent agents (CDAs) in ADMS that switch strategies depending on system conditions to achieve better performance than can be realized by agents that use the same strategies under all system conditions.
These show that there are two major pathways governing the in vivo activity of antimicrobial agents – time-dependent agents such as β-lactams, with efficacy occurring when non-protein-bound drug concentrations exceed MICs of pathogens for greater than 40 50% of the dosing interval, and concentration-dependent agents, with clinical success occurring when AUC MIC ratios exceed threshold values.
Hence, it is desirable to develop ROS-dependent agents for the treatment of thrombocytopenia.
The results question the advisability of the clinical practice of initially giving small daily "loading doses" of proliferation-dependent agents such as FU.
Standard doses of the concentration-dependent agents amikacin and ciprofloxacin proved inadequate to achieve target peak concentrations in ICU patients [ 20, 21].
Thus, these antibody-CVF conjugates might be a promising therapeutic approach, mediating selective complement-dependent agents of human melanoma, leukemia, and neuroblastomas.
In peripheral lymphocytes, chromosome-type CAs are induced by IR and other S-independent clastogens, causing DNA double-strand breaks, whereas chromatid-type CAs are produced by S-dependent agents such as many chemical mutagens.
S phase-dependent agents, such as mitomycin C (MMC) and UV light are among the most effective inducers of SCE [ 26], presumably the conditions that increase the cellular burden of SSBs or subsequent DSBs creation during replication stress generally induce SCE efficiently.
In contrast to concentration-dependent agents, 'achieve the target quickly and maintain it' is the optimal strategy with time-dependent antibacterial agents, namely β-lactams, glycopeptides and oxazolidinones, whose efficacy in severely ill patients is related mainly to the maintenance of supra-inhibitory concentrations.
