A number of researchers in gerontology and geriatrics have proposed focusing on the importance of making autonomous decisions irrespective of frailty, dependency and restrictions of action [ 4, 5, 17, 19].
However, high operator dependency and diagnostic restrictions related to anatomical and clinical presentation may limit consistency of application.
Our study confirmed the impact of gout on patients' lives recognized in the earlier study [ 26], namely, severe pain, dependency, work disability, dietary restrictions and social isolation.
Yet even when software dependency is the only restriction, further ethical quandaries can easily arise: While Siebren Versteeg's Untitled Film II, which he created in Macromedia Director with Lingo, could probably be recreated with a contemporary language that preserves the work's look and feel, "that would be eliminating the trace of the artist's hand," cautions Phillips.
5 9 25–27 The longstanding suffering, the restrictions and the dependency on others, caused distress and a sense of inadequacy.
Moreover, even before onset of treatment patients may already present with pain, impaired swallowing, trismus, aspiration, dietary restrictions and tube dependency, and loss of body weight, because the tumour may disrupt the normal anatomy and thus interfere with normal function [ 1].
Three studies have reported that it was common for patients with COPD to fail to use their oxygen as prescribed by their doctors [ 13, 16, 17], whilst a further study [ 10] found that, whilst LTOT was deemed beneficial, increasing dependency on oxygen imposed lifestyle restrictions.
Furthermore, we show that RNNs learn a subset of the known restrictions on filler gap dependencies, known as island constraints: RNNs show evidence for wh-islands, adjunct islands, and complex NP islands.
The technology has furthermore accelerated the discovery of novel host dependency factors (HDF) and host restriction factors (HRF) in viral infection [ 10- 19].
This method is of low cost and avoids dependency on the availability of restriction enzyme sites in the DNA sequence, as needed in more conventional restriction/ligation-based cloning procedures.
