In the case of HMVECs and HMEC-1 cells, a clear dose-dependency was observed in response to CM from senescent HPMC cultures.
To analyze if a similar dependency could be observed in response to TLR agonists under normoxic conditions, VEGF stimulation by selective TLR ligands was measured in the supernatants of MoDC.
In this paper we examined the site and phase-dependency of gait adaptation in response to non-noxious cutaneous stimulation at five discrete sites on the plantar foot surface.
Although both PDGF and FGF are required in the neural crest for craniofacial development, we find distinct transcriptional programs, effector dependencies, and cellular outcomes in response to each RTK.
Since nsPEFs induced-Bid cleavage and proteases other than caspases can cleave Bid, including calcium-dependent calpains [ 25, 26], we investigated the caspase- and calcium-dependency of Bid cleavage in response to nsPEFs (Fig. 5) as well as the possibility for nsPEF-induced calpain activity (Fig. 6).
This notion reflects our finding of the induction of different p53 target genes in different mutant p53 cell lines after APR-246 treatments, notwithstanding the cellular context dependency exhibited by ES cells in response to APR-246.
Notably, the fact that β-catenin knockdown almost completely reversed the increase in ZEB1 protein and EMT program upon AIF silencing, further supporting β-catenin dependency of the observed phenotypic changes in response to AIF depletion.
For now, big technology companies will undoubtedly continue to grow in response to an increasing dependency on technology from both consumers and other large corporates.
The dose dependency and time course of secreted MMP-1 protein in response to DEPs suggest transcriptional regulation of the MMP-1 gene.
Parity-dependency in estrogen responsiveness was observed with respect to the achieved serum E2 levels in response to similar E2 treatment.
Interestingly, immature vessels are depleted in response to anti-TNF therapy, highlighting the co-dependency of angiogenesis and inflammation [ 6].
