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These methods should explicitly account for the dependencies of expression patterns across time points.
This prevents non-DE genes from contributing to gene modules, as it unlinks dependencies of expression profiles across conditions for those genes (see Section 2.2 below).
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Although it is not surprising that there may be reciprocity or dependency of expression between imprinting intra-cluster gene expression, the significance of this finding in hepatocarcinogenesis needs further investigation.
Signal normalization also helped to reduce the platform-dependency of expression signals.
Furthermore, the transcription analysis of sigA and sigB clarified the different dependency of expression during different growth phases.
To support this contention further studies examining time dependency of expression of IL-6, IL-10 or TNF-α are needed, as is expansion of the range of cytokines to include other key regulators of airway inflammation.
To study the dependency of expression of Mrc1 and miR-511 as well as regulation of TNFR1 on GCs and GR, we adrenalectomized (Adx) mice to remove the major source of GCs.
Hub genes of GRNs reflect the most prominent dependencies of the expression profile to a large number of genes.
The close relation between Cx43 and Stra8 is affirmed by their overlapping regulatory mechanisms, their common requirement during GC development and the dependency of Stra8 expression on Cx43 expression.
In summary, the consistent transcript-dependent components of expression profile dependency on post chip RNA quality can be explained by the distribution of relative probe positions, the length of the mRNA, and probably the stability of the mRNA species.
As we focus here on the adaptation of the regulated lac operon expression, we explicitly incorporate the dependency of the expression level on the lactose concentration by substituting Z = Zreg(L), which yields (2) g = g 0 - η (Z reg (L ) ) + B (Z reg (L ), L ) where Zreg describes the system's regulatory properties and is referred to as the regulatory response or induction profile.
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