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i) To assess online gaming addiction, we adapted the DSM-IV-TR for substance dependence with the same cut-off point (3 or more criteria) as the original in favor of a self-quoted diagnosis of online video game addiction.
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These hits were independently validated by measuring concentration-dependence with the same voltage-sensitive dye, and by visualising the competition of hits with an Alexa-647-ATP fluorophore using confocal microscopy; confocal yielded kon (1.142 × 106 M−1 s−1) and koff (0.136 s−1) for Alexa-647-ATP (Kd = 119 nM).
To assess IA, ii) the Goldberg Internet Addiction Disorder (GIAD) scale is a qualitative scale with 11 items and was adapted from the DSM-IV substance dependence by Goldberg with the same cut-off point as DSM-IV substance dependence (3 or more criteria) indicating Internet addiction [ 8].
To compare the result, we also simulated a data set with no dependence using the same procedure but with the dependence effect d ij = 0.
Variations in other opioid receptor genes were not associated with alcohol dependence in the same large, family-based sample in which the association with OPRK1 was reported (17).
With appropriate parameter constellations it satisfies either the characteristic size dependence or the velocity dependence, but not both with the same parameter setting.
To improve the sensitivity of the scale, the trial altered the scoring of each item from the original two-point scale to scores which ranged from 1 to 4. Scores increased with level of dependence, and the same scoring system was used for both sexes.
For a comparison purpose, we also present this dependence for the same thick films with electrical contacts made of pure Ag paste (Fig. 2) plotted on the basis of previous results [15, 16].
V ext is the scalar potential associated with the external terms that consists of degree 1 coefficients, ({q_{1}^{m}}(t)), with piecewise linear time dependence over the same periods defined by the knots of V int.
A comparison with elastin (Fig. 7(a)) shows that the tissue sample intensity dependence follows the same trend.
Partial area increase can be described by nearly the same dependence with the exception that it decreases gradually to ~ 2% at ν =1.
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