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We acknowledge greater amplitude dependence on dose in the model (subsection "Cooperative IKK activation underlies dose-dependent response delay") and add notes to indicate the changing y-scale in Figure 3 figure supplement 1 and Figure 4 figure supplement 1. Figure 5 figure supplement 1B represents analysis of the traces presented in Figure 5 figure supplement 1A.
One limitation of the NOAEL/LOAEL approach in selecting points of departure for exposure limits is its dependence on dose selection/study design.
The irradiation creep rate exhibited a linear dependence on applied tensile stress, dose rate, and temperature and no dependence on dose to a total accumulated value of 1.0 dpa.
The term "pharmacokinetics" denotes what the body does to the drug in terms of its absorption, distribution, metabolism, and excretion, including the concentration-time relationship and its dependence on dose, the term "pharmacodynamics" denotes what the drug does to the body [6].
After the 24 h treatment with ZnO NPs, the effect was also clear and a significant increase in DNA damage was observed at tested doses of 25, 50, 75, and 100 μg·mL−1, with a significant dependence on dose (Figure 6A).
IL-6 was increased for all ALI exposure scenarios, but no significant dependence on dose or time was observed.
Similar(51)
Dependence severity did not significantly alter response to reduced nicotine content cigarettes on the Minnesota Tobacco Withdrawal Scale nor Questionnaire of Smoking Urges-brief (QSU) Factor-2 scale; dependence severity and dose interacted significantly on the QSU-brief Factor-1 scale, with reductions dependent on dose among highly but not mildly or moderately dependent smokers.
The highest number of affected transcripts was detected in the lungs, with a complex dependence on absorbed dose.
In HEK293 cells an increase in DNA damage was observed after the treatment with ZnO NPs, and there was a clear dependence on the dose.
Two main features were evident: the reaction advance dependence on the dose of mechanical energy and a slowing down in the reaction kinetics for n∼0.5 associated with the saturation of surface sites.
Nucleolus size showed a nonlinear dependence on oxaliplatin dose at 24 h after treatment (r=0.99).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com