A well-characterized example is the finding that six Cdc28-dependent phosphorylation events on Sic1 are required for its recognition by Cdc4; this multisite dependence confers ultrasensitive or switch-like behavior on the degradation of Sic1 (42).
Nutritional status and nutrition-related parameters such as weight loss, quantity of food intake, appetite, arm circumference, dietary type, and extent of dependence confer considerable prognostic value regarding hospital LOS in acute care setting.
For example, a subset of CBR-resistant mutations in rpoC conferred dependence on the inhibitor for growth of the mutant strains [ 19], indicating that their phenotypes cannot be explained by the loss of CBR binding.
However, Shimamura et al (2005) recently reported that certain EGFR kinase domain mutations which occur in a sub-population of non-small cell lung cancer (NSCLC) and which enhance sensitivity to EGFR inhibitors, also conferred dependence on Hsp90 and resulted in acquired sensitivity of the mature protein to Hsp90 inhibition.
Recent analyses indicate that mutualistic networks have specific signatures in their topology and structure (i.e., the way species are interconnected through mutual dependences) that confer more robustness and stability than expected for randomly assembled interactions (Bascompte and Jordano 2007).
Although wild-type AAV6 does not depend on HSPG for infection [13], ShH10 exhibits a newly conferred HSPG dependence, allowing it to better bind and traverse the ILM (Fig. 6b).
The nonconducting phenotype of E268A CLC-5 led to the hypothesis that the voltage dependence of CLC-5 was conferred by movement of protons in the voltage field from E268 to E211 (23).
Thus, evidence from human, murine, and cellular models indicates that mutant EGFR is oncogenic and confers dependence on EGFR for NSCLC cell survival.
Because cohesin cleavage also destroys the tension responsible for turning off the SAC, cells must possess a mechanism to prevent SAC reactivation during anaphase, which could be conferred by a dependence of the SAC on Cdk1 [ 3 5].
These calculations suggest that the heterozygote advantage for fecundity conferred by BMP15 has some dependence on environmental conditions.
