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Knockout of single HDAC family members in mice produces a variety of phenotypes ranging from early embryonic death to viable animals with only discrete alterations, indicating that potential side effects of HDAC inhibitors depend on the selectivity of the compounds.
As retinoids exert their effect through their binding to RARs or RXRs, their biological effects largely depend on the selectivity of receptors.
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Moreover, the information value of an event depends on the selectivity of selection.
Finally, the selectivity of the combination of pharmacophores also depended on the selectivity of the NRs ligands.
Stable dispersions have been obtained in polar (DMF) and apolar (heptane) media depending on the selectivity of the diblock copolymers.
As a result membrane cascades seem most promising for large scale continuous processes for producing pure but depending on the selectivity not ultrapure products.
The estimated changes in the length at maturity suggest that fisheries shift a phenotypic mean value to different directions and at different relative magnitudes depending on the selectivity curve(s) of the fishing gear(s).
Successful imaging or treatment of neuroblastoma with 131I-meta-iodobenzylguanidine (131I-mIBG) depends on the selectivity of active (type 1) uptake of mIBG in neuroblastoma cells relative to passive (type 2) uptake present in most normal tissues.
Physiological signaling from cilia critically depends on the selectivity of receptor targeting to the ciliary membrane, and disturbances in this targeting are thought to underlie a variety of pathological conditions (Hsiao et al., 2012).
Retentate nitrogen concentration and stage-cut depend on the membrane properties oxygen nitrogen selectivity, oxygen permeance and membrane area as well as on the operating parameters, feed pressure, permeate pressure and feed flow rate.
Both activity and selectivity depend on the time on stream.
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CEO of Professional Science Editing for Scientists @ prosciediting.com