Using fluorescent NPs, we show that these signals do not depend on NPs internalization, are totally ascribable to calcium influx and are dependent in a complex way from size and surface charge.
Here we hypothesize the CeNMs may play an important role in protecting the capacity of stem cells against the oxidative insult, and the suppression mechanism of ROS level may depend on the internalization of CeNMs.
The mechanisms of action of BoNTs on neurotransmitter release depend on toxin internalization into neurons and the specific cleavage of synaptic proteins.
Together these data indicate that α2AAR-YFP/CFP-mediated chemotaxis, calcium mobilization and ERK2 phosphorylation, which are comparable with the responses elicited by the endogenous CCR2, do not depend on receptor internalization.
One might assume that cholesterol levels depend on the internalization rate of LDL and the behavior of L i.
Our study suggests that the beneficial anxiolytic/antidepressant-like effects of chronic SSRI treatment indeed depend on 5-HT1A autoreceptor internalization, but do not require a sustained increase in extracellular 5-HT levels in a territory of 5-HT projection such as hippocampus.
We were able to show that i) clathrin or CAV1 inhibition/interference blocks IGF1R internalization, ii) IGF1R signaling in ES largely depends on receptor internalization, and iii) the pro-survival and anti-apoptotic effects of IGF1R signaling are considerably reduced when internalization is blocked.
The effects of the drug combination had an impact on the phosphorylation status of several proteins, namely AKT, SRC p38, TOR, MSK1/2, MEK1/2, among others, confirming once again that IGF1R signaling depends on its internalization.
For TLN, the area percentages differed, as TLN's distribution varied depending on its internalization.
