Signalling functions of Ras critically depend on their anchoring in the cytoplasmic leaflet of the plasma membrane by lipid-modifications [ 64].
The MID may change depending on the anchor used, the definition of 'important change' for that anchor, the type of anchor, the baseline values and the direction of change [ 14, 18].
It is as though an impulse alone had a truth that didn't depend on its being anchored to the world.
In a study of intervertebral disk herniation, anchor-based MCID estimates for the US-scored EQ-5D ranged from 0.08-0.17 depending on the anchor used [ 20].
It's a simple and clever conceit, but one that depends on an anchoring star who is, in effect, the Jamesian central consciousness.
It all depended on the anchor man for each team and when Charles held his nerve and steered Vindicat, the least experienced horse on the British team, clear over every fence and landed over the last, the Tower Bridge, with daylight to spare, victory was assured.
The institutions we have historically depended on to anchor us seem adrift.
However, the estimated factor mean difference may be different depending on the anchor items selected for the factor [ 57].
The evaluation of data around the MID was based on the change from the baseline in the SOBDA score for those patients who endorsed or had the clinician endorse for them, (depending on the anchor), the response category 'better' for the global assessments or the prespecified grouping of meaningful improvement on other measures (PGAC, CGI-C, CRQ-SAS and FEV1).
"Malls depended on being anchored by two department stores, one at either end," he says.
